Pub. Date : 2016 Nov 15
PMID : 27542283
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MARCKS upregulation was confirmed on protein level and also observed in other BTZ-resistant tumor cell lines as well as in leukemia cells with acquired resistance to other proteasome inhibitors. | Bortezomib | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 2 | Moreover, when MARCKS protein expression was demonstrated in specimens derived from therapy-refractory pediatric leukemia patients (n = 44), higher MARCKS protein expression trended (p = 0.073) towards a dismal response to BTZ-containing chemotherapy. | Bortezomib | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 3 | Moreover, when MARCKS protein expression was demonstrated in specimens derived from therapy-refractory pediatric leukemia patients (n = 44), higher MARCKS protein expression trended (p = 0.073) towards a dismal response to BTZ-containing chemotherapy. | Bortezomib | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 4 | Mechanistically, we show a BTZ concentration-dependent association of MARCKS protein levels with the emergence of ubiquitin-containing vesicles in BTZ-resistant CEM cells. | Bortezomib | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 5 | Mechanistically, we show a BTZ concentration-dependent association of MARCKS protein levels with the emergence of ubiquitin-containing vesicles in BTZ-resistant CEM cells. | Bortezomib | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 6 | Consistent with these observations, MARCKS protein associated with ubiquitin-containing vesicles was also more prominent in clinical leukemic specimen with ex vivo BTZ resistance compared to BTZ-sensitive leukemia cells. | Bortezomib | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 7 | Consistent with these observations, MARCKS protein associated with ubiquitin-containing vesicles was also more prominent in clinical leukemic specimen with ex vivo BTZ resistance compared to BTZ-sensitive leukemia cells. | Bortezomib | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 8 | Collectively, we propose a role for MARCKS in a novel mechanism of BTZ resistance via exocytosis of ubiquitinated proteins in BTZ-resistant cells leading to quenching of proteolytic stress. | Bortezomib | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 9 | Collectively, we propose a role for MARCKS in a novel mechanism of BTZ resistance via exocytosis of ubiquitinated proteins in BTZ-resistant cells leading to quenching of proteolytic stress. | Bortezomib | myristoylated alanine rich protein kinase C substrate | Homo sapiens |