Pub. Date : 2016 Aug 17
PMID : 27535909
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In adult Fos-lacZ transgenic rats, selective inactivation of nicotine-cue-activated Fos neurons in central amygdala, but not orbitofrontal cortex, decreased "incubated" nicotine seeking on withdrawal day 14. | Nicotine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 2 | In adult Fos-lacZ transgenic rats, selective inactivation of nicotine-cue-activated Fos neurons in central amygdala, but not orbitofrontal cortex, decreased "incubated" nicotine seeking on withdrawal day 14. | Nicotine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 3 | In adult Fos-lacZ transgenic rats, selective inactivation of nicotine-cue-activated Fos neurons in central amygdala, but not orbitofrontal cortex, decreased "incubated" nicotine seeking on withdrawal day 14. | Nicotine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 4 | Here, we used a rat model of incubation of drug craving, the neuronal activity marker Fos, and the Daun02 chemogenetic inactivation method to demonstrate that incubation of nicotine craving is also observed after adolescent-onset nicotine self-administration and that neuronal ensembles in the central nucleus of the amygdala play a critical role in this incubation in adult rats. | Nicotine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |