Title : Associations of the CYP3A5*3 and CYP3A4*1G polymorphisms with the pharmacokinetics of oral midazolam and the urinary 6β-hydroxycortisol/cortisol ratio as markers of CYP3A activity in healthy male Chinese.

Pub. Date : 2016 Oct

PMID : 27511886






2 Functional Relationships(s)
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1 Associations of the CYP3A5*3 and CYP3A4*1G polymorphisms with the pharmacokinetics of oral midazolam and the urinary 6beta-hydroxycortisol/cortisol ratio as markers of CYP3A activity in healthy male Chinese. Midazolam cytochrome P450 family 3 subfamily A member 5 Homo sapiens
2 METHODS: Single oral 15 mg doses of midazolam were given to 20 healthy male Chinese subjects who were genotyped for the CYP3A5*3 and CYP3A4*1G polymorphisms. Midazolam cytochrome P450 family 3 subfamily A member 5 Homo sapiens