Title : The Myeloablative Drug Busulfan Converts Cysteine to Dehydroalanine and Lanthionine in Redoxins.

Pub. Date : 2016 Aug 23

PMID : 27490699






1 Functional Relationships(s)
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1 In contrast, here we demonstrate that incubation of busulfan with the thiol redox proteins glutaredoxin or thioredoxin at pH 7.4 and 37 C results in the formation of putative S-tetrahydrothiophenium adducts at their catalytic Cys residues, followed by beta-elimination to yield dehydroalanine. Busulfan glutaredoxin Homo sapiens