Pub. Date : 2016 Aug 9
PMID : 27477280
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We report that mutant KRAS regulates intracellular fatty acid metabolism through Acyl-coenzyme A (CoA) synthetase long-chain family member 3 (ACSL3), which converts fatty acids into fatty Acyl-CoA esters, the substrates for lipid synthesis and beta-oxidation. | Fatty Acids | acyl-CoA synthetase long chain family member 3 | Homo sapiens |
| 2 | We report that mutant KRAS regulates intracellular fatty acid metabolism through Acyl-coenzyme A (CoA) synthetase long-chain family member 3 (ACSL3), which converts fatty acids into fatty Acyl-CoA esters, the substrates for lipid synthesis and beta-oxidation. | Fatty Acids | acyl-CoA synthetase long chain family member 3 | Homo sapiens |
| 3 | Furthermore, mutant KRAS promotes the cellular uptake, retention, accumulation, and beta-oxidation of fatty acids in lung cancer cells in an ACSL3-dependent manner. | Fatty Acids | acyl-CoA synthetase long chain family member 3 | Homo sapiens |