Protein Name acyl-CoA synthetase long chain family member 3
Organism Homo sapiens
Gene ID 2181
Gene Symbol


UniProt O95573 (ACSL3_HUMAN), A0A024R487 (A0A024R487_HUMAN)
Relationships Total Number of functionally related compound(s) : 51
Total Number of Articles : 36

acyl-CoA synthetase long chain family member 3

Gene Summary

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

  • fatty acid CoA ligase Acsl3
  • arachidonate--CoA ligase
  • fatty-acid-Coenzyme A ligase, long-chain 3
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