Pub. Date : 2016
PMID : 27403417
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin Alleviated Abeta-Induced Apoptosis via the Suppression of JNK MAPK Signaling Pathway in Cultured Hippocampal Neurons. | Metformin | amyloid beta precursor protein | Homo sapiens |
| 2 | The aim of the current study is to investigate the role of metformin in Abeta-induced cytotoxicity and explore the underlying mechanisms. | Metformin | amyloid beta precursor protein | Homo sapiens |
| 3 | First, the experimental results show that metformin salvaged the neurons exposed to Abeta in a concentration-dependent manner with MTT and LDH assay. | Metformin | amyloid beta precursor protein | Homo sapiens |
| 4 | Metformin decreased hyperphosphorylated JNK induced by Abeta; however, the protection of metformin against Abeta was blocked when anisomycin, the activator of JNK, was added to the medium, indicating that metformin performed its protection against Abeta in a JNK-dependent way. | Metformin | amyloid beta precursor protein | Homo sapiens |
| 5 | Metformin decreased hyperphosphorylated JNK induced by Abeta; however, the protection of metformin against Abeta was blocked when anisomycin, the activator of JNK, was added to the medium, indicating that metformin performed its protection against Abeta in a JNK-dependent way. | Metformin | amyloid beta precursor protein | Homo sapiens |
| 6 | Metformin decreased hyperphosphorylated JNK induced by Abeta; however, the protection of metformin against Abeta was blocked when anisomycin, the activator of JNK, was added to the medium, indicating that metformin performed its protection against Abeta in a JNK-dependent way. | Metformin | amyloid beta precursor protein | Homo sapiens |
| 7 | Taken together, our findings demonstrate that metformin may have a positive effect on Abeta-induced cytotoxicity, which provides a preclinical strategy against AD for elders with diabetes. | Metformin | amyloid beta precursor protein | Homo sapiens |