PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27403417-0	2016	Metformin Alleviated Abeta-Induced Apoptosis via the Suppression of JNK MAPK Signaling Pathway in Cultured Hippocampal Neurons.	Metformin	0-9	amyloid beta precursor protein	Homo sapiens	21-26	
27403417-3	2016	The aim of the current study is to investigate the role of metformin in Abeta-induced cytotoxicity and explore the underlying mechanisms.	Metformin	59-68	amyloid beta precursor protein	Homo sapiens	72-77	
27403417-4	2016	First, the experimental results show that metformin salvaged the neurons exposed to Abeta in a concentration-dependent manner with MTT and LDH assay.	Metformin	42-51	amyloid beta precursor protein	Homo sapiens	84-89	
27403417-7	2016	Metformin decreased hyperphosphorylated JNK induced by Abeta; however, the protection of metformin against Abeta was blocked when anisomycin, the activator of JNK, was added to the medium, indicating that metformin performed its protection against Abeta in a JNK-dependent way.	Metformin	0-9	amyloid beta precursor protein	Homo sapiens	55-60	
27403417-7	2016	Metformin decreased hyperphosphorylated JNK induced by Abeta; however, the protection of metformin against Abeta was blocked when anisomycin, the activator of JNK, was added to the medium, indicating that metformin performed its protection against Abeta in a JNK-dependent way.	Metformin	89-98	amyloid beta precursor protein	Homo sapiens	107-112	
27403417-7	2016	Metformin decreased hyperphosphorylated JNK induced by Abeta; however, the protection of metformin against Abeta was blocked when anisomycin, the activator of JNK, was added to the medium, indicating that metformin performed its protection against Abeta in a JNK-dependent way.	Metformin	89-98	amyloid beta precursor protein	Homo sapiens	107-112	
27403417-9	2016	Taken together, our findings demonstrate that metformin may have a positive effect on Abeta-induced cytotoxicity, which provides a preclinical strategy against AD for elders with diabetes.	Metformin	46-55	amyloid beta precursor protein	Homo sapiens	86-91