Pub. Date : 2016 Aug
PMID : 27154061
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ADRB2 signaling promotes HCC progression and sorafenib resistance by inhibiting autophagic degradation of HIF1alpha. | Sorafenib | adrenergic receptor, beta 2 | Mus musculus |
| 2 | Notably, ADRB2 signaling negatively regulated autophagy by disrupting Beclin1/VPS34/Atg14 complex in an Akt-dependent manner, leading to HIF1alpha stabilization, reprogramming of HCC cells glucose metabolism, and the acquisition of resistance to sorafenib. | Sorafenib | adrenergic receptor, beta 2 | Mus musculus |
| 3 | Conversely, inhibition of ADRB2 signaling by ICI118,551, or knockdown ADRB2 expression, led to enhanced autophagy, HIF1alpha destabilization, tumor growth suppression, and improved anti-tumor activity of sorafenib. | Sorafenib | adrenergic receptor, beta 2 | Mus musculus |
| 4 | Conversely, inhibition of ADRB2 signaling by ICI118,551, or knockdown ADRB2 expression, led to enhanced autophagy, HIF1alpha destabilization, tumor growth suppression, and improved anti-tumor activity of sorafenib. | Sorafenib | adrenergic receptor, beta 2 | Mus musculus |
| 5 | Given the efficacy of ADRB2 modulation on HCC inhibition and sorafenib resistance, adrenoceptor antagonist appears to be a putative novel treatment for HCC and chemoresistance. | Sorafenib | adrenergic receptor, beta 2 | Mus musculus |
| 6 | ADRB2 signaling negatively regulated autophagy, leading to hypoxia-inducible factor-1alpha stabilization, reprogramming of hepatocellular carcinoma cells glucose metabolism, and the acquisition of resistance to sorafenib. | Sorafenib | adrenergic receptor, beta 2 | Mus musculus |