Title : ADRB2 signaling promotes HCC progression and sorafenib resistance by inhibiting autophagic degradation of HIF1α.

Pub. Date : 2016 Aug

PMID : 27154061






1 Functional Relationships(s)
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1 Notably, ADRB2 signaling negatively regulated autophagy by disrupting Beclin1/VPS34/Atg14 complex in an Akt-dependent manner, leading to HIF1alpha stabilization, reprogramming of HCC cells glucose metabolism, and the acquisition of resistance to sorafenib. Sorafenib beclin 1, autophagy related Mus musculus