Protein Name beclin 1, autophagy related
Organism Mus musculus
Gene ID 56208
Gene Symbol

Becn1

UniProt O88597 (BECN1_MOUSE)
Relationships Total Number of functionally related compound(s) : 340
Total Number of Articles : 436
Description

beclin 1, autophagy related

Gene Summary

Enables identical protein binding activity. Involved in several processes, including autophagy of mitochondrion; cellular response to glucose starvation; and engulfment of apoptotic cell. Acts upstream of or within several processes, including amyloid-beta metabolic process; negative regulation of autophagosome assembly; and positive regulation of cardiac muscle hypertrophy. Located in autophagosome; phagocytic vesicle; and trans-Golgi network. Part of phosphatidylinositol 3-kinase complex, class III. Is expressed in central nervous system; extraembryonic visceral endoderm; sensory organ; and spleen. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Machado-Joseph disease. Orthologous to human BECN1 (beclin 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • beclin-1
  • Bcl-2-interacting protein beclin
  • Beclin-1
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Properties