Title : Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs.

Pub. Date : 2016 May

PMID : 27133040






2 Functional Relationships(s)
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1 Simultaneously, ALA could inhibit activation of ER stress-associated sensors GRP78, IRE1alpha, ATF6, P-PERK, P-eIF2alpha, CHOP and ATF4 induced by HCY. Thioctic Acid activating transcription factor 4 Homo sapiens
2 In addition, using GSH inhibitor, we proved ALA reduced the expressions of GRP78, ATF4 and IRE1alpha by generating GSH. Thioctic Acid activating transcription factor 4 Homo sapiens