Pub. Date : 2016 Apr
PMID : 27106025
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Photoexcited nanocurcumin induced phosphorylation of c-Jun N-terminal kinase (JNK), mitochondrial depolarization, caspase-3 activation, and cleavage of poly (ADP-ribose) polymerase, indicating apoptotic cell death. | nanocurcumin | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Photoexcited nanocurcumin induced phosphorylation of c-Jun N-terminal kinase (JNK), mitochondrial depolarization, caspase-3 activation, and cleavage of poly (ADP-ribose) polymerase, indicating apoptotic cell death. | nanocurcumin | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Accordingly, pharmacologial inhibition of JNK and caspase activity rescued cancer cells from photoexcited nanocurcumin. | nanocurcumin | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | By demonstrating the ability of photoexcited nanocurcumin to induce oxidative-stress independent, JNK- and caspase-dependent apoptosis, our results support its further investigation in cancer therapy. | nanocurcumin | mitogen-activated protein kinase 8 | Homo sapiens |