Title : Lipoic Acid Exerts Antioxidant and Anti-inflammatory Effects in Response to Heat Shock in C2C12 Myotubes.

Pub. Date : 2016 Jun

PMID : 27086282






8 Functional Relationships(s)
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1 Moreover, lipoic acid treatment for 3 h increased and promoted heat shock-induced interleukin (IL)-6 mRNA and protein levels and that for 24 h downregulated IL-6 mRNA expression, suggesting a dual effect of lipoic acid on IL-6 regulation. Thioctic Acid interleukin 6 Homo sapiens
2 Moreover, lipoic acid treatment for 3 h increased and promoted heat shock-induced interleukin (IL)-6 mRNA and protein levels and that for 24 h downregulated IL-6 mRNA expression, suggesting a dual effect of lipoic acid on IL-6 regulation. Thioctic Acid interleukin 6 Homo sapiens
3 Moreover, lipoic acid or heat shock alone upregulated the IL-6 receptor (IL-6R-alpha) and glycoprotein 130 (gp130) mRNA expression followed by IL-6 expression; these data indicate that the regulation of lipoic acid or heat shock is mediated by IL-6R signaling, thus suggesting that C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock. Thioctic Acid interleukin 6 Homo sapiens
4 Moreover, lipoic acid or heat shock alone upregulated the IL-6 receptor (IL-6R-alpha) and glycoprotein 130 (gp130) mRNA expression followed by IL-6 expression; these data indicate that the regulation of lipoic acid or heat shock is mediated by IL-6R signaling, thus suggesting that C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock. Thioctic Acid interleukin 6 Homo sapiens
5 Moreover, lipoic acid or heat shock alone upregulated the IL-6 receptor (IL-6R-alpha) and glycoprotein 130 (gp130) mRNA expression followed by IL-6 expression; these data indicate that the regulation of lipoic acid or heat shock is mediated by IL-6R signaling, thus suggesting that C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock. Thioctic Acid interleukin 6 Homo sapiens
6 Moreover, lipoic acid or heat shock alone upregulated the IL-6 receptor (IL-6R-alpha) and glycoprotein 130 (gp130) mRNA expression followed by IL-6 expression; these data indicate that the regulation of lipoic acid or heat shock is mediated by IL-6R signaling, thus suggesting that C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock. Thioctic Acid interleukin 6 Homo sapiens
7 Moreover, lipoic acid or heat shock alone upregulated the IL-6 receptor (IL-6R-alpha) and glycoprotein 130 (gp130) mRNA expression followed by IL-6 expression; these data indicate that the regulation of lipoic acid or heat shock is mediated by IL-6R signaling, thus suggesting that C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock. Thioctic Acid interleukin 6 Homo sapiens
8 Moreover, lipoic acid or heat shock alone upregulated the IL-6 receptor (IL-6R-alpha) and glycoprotein 130 (gp130) mRNA expression followed by IL-6 expression; these data indicate that the regulation of lipoic acid or heat shock is mediated by IL-6R signaling, thus suggesting that C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock. Thioctic Acid interleukin 6 Homo sapiens