Pub. Date : 2016 May 25
PMID : 27022819
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine excites corticotropin-releasing hormone mRNA-expressing neuron in the hypothalamic paraventricular nucleus in vitro in rats. | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 2 | Nicotine is known to modulate the activity of the hypothalamic-pituitary-adrenal axis by stimulating corticotropin-releasing hormone (CRH) release from the hypothalamic paraventricular nucleus (PVN). | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 3 | Nicotine is known to modulate the activity of the hypothalamic-pituitary-adrenal axis by stimulating corticotropin-releasing hormone (CRH) release from the hypothalamic paraventricular nucleus (PVN). | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 4 | However, the mechanism by which nicotine affects the hypothalamic-pituitary-adrenal axis by modulating PVN CRH neuronal activity is currently unclear. | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 5 | Under current-clamp recording conditions, application of nicotine (1 muM) induced excitation in 92% (23/25) PVN CRH-mRNA-expressing neurons, which showed a significant increase in the spike firing rate accompanied by a depolarization of the membrane potential. | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 6 | Nicotine induced an increase in the spike firing rate of PVN CRH-mRNA-expressing neurons in a concentration-dependent manner. | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 7 | The half-effective concentration (EC50) of nicotine for increasing the spike firing rate of PVN CRH-mRNA-expressing neurons was 1.6 muM. | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 8 | Extracellular application of ionotropic glutamate receptor antagonist kynurenic acid (1 mM) abolished the nicotine-induced excitation of PVN CRH-mRNA-expressing neurons. | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 9 | Biocytin staining confirmed that the nicotine-sensitive CRH-mRNA-expressing neurons were located in the PVN parvocellular division. | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 10 | These results indicated that extracellular administration of nicotine indirectly excited PVN CRH-mRNA-expressing neurons, suggesting that nicotine modulated PVN CRH secretion by enhancement of both the presynaptic action potential drive and quantal glutamate release. | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 11 | These results indicated that extracellular administration of nicotine indirectly excited PVN CRH-mRNA-expressing neurons, suggesting that nicotine modulated PVN CRH secretion by enhancement of both the presynaptic action potential drive and quantal glutamate release. | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 12 | These results indicated that extracellular administration of nicotine indirectly excited PVN CRH-mRNA-expressing neurons, suggesting that nicotine modulated PVN CRH secretion by enhancement of both the presynaptic action potential drive and quantal glutamate release. | Nicotine | corticotropin releasing hormone | Rattus norvegicus |
| 13 | These results indicated that extracellular administration of nicotine indirectly excited PVN CRH-mRNA-expressing neurons, suggesting that nicotine modulated PVN CRH secretion by enhancement of both the presynaptic action potential drive and quantal glutamate release. | Nicotine | corticotropin releasing hormone | Rattus norvegicus |