PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27022819-0	2016	Nicotine excites corticotropin-releasing hormone mRNA-expressing neuron in the hypothalamic paraventricular nucleus in vitro in rats.	Nicotine	0-8	corticotropin releasing hormone	Rattus norvegicus	17-48	
27022819-1	2016	Nicotine is known to modulate the activity of the hypothalamic-pituitary-adrenal axis by stimulating corticotropin-releasing hormone (CRH) release from the hypothalamic paraventricular nucleus (PVN).	Nicotine	0-8	corticotropin releasing hormone	Rattus norvegicus	101-132	
27022819-1	2016	Nicotine is known to modulate the activity of the hypothalamic-pituitary-adrenal axis by stimulating corticotropin-releasing hormone (CRH) release from the hypothalamic paraventricular nucleus (PVN).	Nicotine	0-8	corticotropin releasing hormone	Rattus norvegicus	134-137	
27022819-2	2016	However, the mechanism by which nicotine affects the hypothalamic-pituitary-adrenal axis by modulating PVN CRH neuronal activity is currently unclear.	Nicotine	32-40	corticotropin releasing hormone	Rattus norvegicus	107-110	
27022819-5	2016	Under current-clamp recording conditions, application of nicotine (1 muM) induced excitation in 92% (23/25) PVN CRH-mRNA-expressing neurons, which showed a significant increase in the spike firing rate accompanied by a depolarization of the membrane potential.	Nicotine	57-65	corticotropin releasing hormone	Rattus norvegicus	112-115	
27022819-6	2016	Nicotine induced an increase in the spike firing rate of PVN CRH-mRNA-expressing neurons in a concentration-dependent manner.	Nicotine	0-8	corticotropin releasing hormone	Rattus norvegicus	61-64	
27022819-7	2016	The half-effective concentration (EC50) of nicotine for increasing the spike firing rate of PVN CRH-mRNA-expressing neurons was 1.6 muM.	Nicotine	43-51	corticotropin releasing hormone	Rattus norvegicus	96-99	
27022819-8	2016	Extracellular application of ionotropic glutamate receptor antagonist kynurenic acid (1 mM) abolished the nicotine-induced excitation of PVN CRH-mRNA-expressing neurons.	Nicotine	106-114	corticotropin releasing hormone	Rattus norvegicus	141-144	
27022819-10	2016	Biocytin staining confirmed that the nicotine-sensitive CRH-mRNA-expressing neurons were located in the PVN parvocellular division.	Nicotine	37-45	corticotropin releasing hormone	Rattus norvegicus	56-59	
27022819-11	2016	These results indicated that extracellular administration of nicotine indirectly excited PVN CRH-mRNA-expressing neurons, suggesting that nicotine modulated PVN CRH secretion by enhancement of both the presynaptic action potential drive and quantal glutamate release.	Nicotine	61-69	corticotropin releasing hormone	Rattus norvegicus	93-96	
27022819-11	2016	These results indicated that extracellular administration of nicotine indirectly excited PVN CRH-mRNA-expressing neurons, suggesting that nicotine modulated PVN CRH secretion by enhancement of both the presynaptic action potential drive and quantal glutamate release.	Nicotine	61-69	corticotropin releasing hormone	Rattus norvegicus	161-164	
27022819-11	2016	These results indicated that extracellular administration of nicotine indirectly excited PVN CRH-mRNA-expressing neurons, suggesting that nicotine modulated PVN CRH secretion by enhancement of both the presynaptic action potential drive and quantal glutamate release.	Nicotine	138-146	corticotropin releasing hormone	Rattus norvegicus	93-96	
27022819-11	2016	These results indicated that extracellular administration of nicotine indirectly excited PVN CRH-mRNA-expressing neurons, suggesting that nicotine modulated PVN CRH secretion by enhancement of both the presynaptic action potential drive and quantal glutamate release.	Nicotine	138-146	corticotropin releasing hormone	Rattus norvegicus	161-164