Title : Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors.

Pub. Date : 2016 Mar 10

PMID : 26985323






1 Functional Relationships(s)
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1 Research focused on optimization of a crucial HDM2 Trp23-ligand interaction led to the identification of 2-(trifluoromethyl)thiophene as the preferred moiety. 2-(Trifluoromethyl)thiophene MDM2 proto-oncogene Homo sapiens