Title : Mechanism of LHRH-stimulated steroidogenesis in rat Leydig cells: lipoxygenase products of arachidonic acid may not be involved.

Pub. Date : 1989 Nov-Dec

PMID : 2695506






5 Functional Relationships(s)
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1 In the presence of LHRH-A, the stimulatory effect of arachidonic acid was additive up to a concentration of 100 microM; but higher concentrations of arachidonic acid (200 microM) were inhibitory. Arachidonic Acid gonadotropin releasing hormone 1 Rattus norvegicus
2 In the presence of LHRH-A, the stimulatory effect of arachidonic acid was additive up to a concentration of 100 microM; but higher concentrations of arachidonic acid (200 microM) were inhibitory. Arachidonic Acid gonadotropin releasing hormone 1 Rattus norvegicus
3 LHRH-A-induced steroidogenesis was inhibited by 5, 8, 11, 14 Eicosatetraynoic acid (ETYA), an inhibitor of all the three known pathways of arachidonic acid metabolism, and by nordihydroguaiaretic acid, and inhibitory of the lipoxygenase pathway of arachidonic acid metabolism. Arachidonic Acid gonadotropin releasing hormone 1 Rattus norvegicus
4 LHRH-A-induced steroidogenesis was inhibited by 5, 8, 11, 14 Eicosatetraynoic acid (ETYA), an inhibitor of all the three known pathways of arachidonic acid metabolism, and by nordihydroguaiaretic acid, and inhibitory of the lipoxygenase pathway of arachidonic acid metabolism. Arachidonic Acid gonadotropin releasing hormone 1 Rattus norvegicus
5 These results suggest that arachidonic acid, whose release is influenced by phospholipase C, is involved in LHRH-A-induced T secretion by rat Leydig cells. Arachidonic Acid gonadotropin releasing hormone 1 Rattus norvegicus