Title : Design, Synthesis, and Biological Evaluation of New 2-Phenyl-4H-chromen-4-one Derivatives as Selective Cyclooxygenase-2 Inhibitors.

Pub. Date : 2015 Jan-Mar

PMID : 26839798






2 Functional Relationships(s)
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1 Design, Synthesis, and Biological Evaluation of New 2-Phenyl-4H-chromen-4-one Derivatives as Selective Cyclooxygenase-2 Inhibitors. flavone prostaglandin-endoperoxide synthase 2 Homo sapiens
2 In order to develop new selective COX-2 inhibitors, a new series of 2-phenyl-4H-chromen-4-one derivatives possessing a methylsulfonyl pharmacophore group at the para position of the C-4 phenyl ring were designed, synthesized, and evaluated for cyclooxygenase-2 inhibitory activity. flavone prostaglandin-endoperoxide synthase 2 Homo sapiens