Pub. Date : 2016 Jan
PMID : 26612383
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Evaluation of brain SERT occupancy by resveratrol against MDMA-induced neurobiological and behavioral changes in rats: A 4-[18F]-ADAM/small-animal PET study. | N-Methyl-3,4-methylenedioxyamphetamine | solute carrier family 6 member 4 | Rattus norvegicus |
| 2 | MDMA abusers are often accompanied by long-term serotonergic neurotoxicity, which is associated with reduced density of cerebral serotonin transporters (SERT) and depressive disorders. | N-Methyl-3,4-methylenedioxyamphetamine | solute carrier family 6 member 4 | Rattus norvegicus |
| 3 | MDMA abusers are often accompanied by long-term serotonergic neurotoxicity, which is associated with reduced density of cerebral serotonin transporters (SERT) and depressive disorders. | N-Methyl-3,4-methylenedioxyamphetamine | solute carrier family 6 member 4 | Rattus norvegicus |
| 4 | In this study, we examined binding potency of RSV and MDMA to SERT using small-animal positron emission tomography (PET) with the SERT radioligand, N,N-dimethyl-2-(2-amino-4-[(18)F]fluorophenylthio)benzylamine (4-[(18)F]-ADAM) and investigated the protection of RSV against the acute and long-term adverse effects of MDMA. | N-Methyl-3,4-methylenedioxyamphetamine | solute carrier family 6 member 4 | Rattus norvegicus |
| 5 | Further, 4-[(18)F]-ADAM PET imaging revealed that RSV protected against the MDMA-induced decrease in SERT availability in the midbrain and the thalamus 2 weeks following the co-treatment. | N-Methyl-3,4-methylenedioxyamphetamine | solute carrier family 6 member 4 | Rattus norvegicus |