CPRiL

Protein Name	solute carrier family 6 member 4
Organism	Rattus norvegicus
Gene ID	25553
Gene Symbol	Slc6a4
UniProt	P31652 (SC6A4_RAT)
Relationships	Total Number of functionally related compound(s) : 424 Total Number of Articles : 589
Description	solute carrier family 6 member 4
Gene Summary	Enables several functions, including cocaine binding activity; monoatomic cation transmembrane transporter activity; and syntaxin-1 binding activity. Involved in several processes, including behavioral response to cocaine; cellular response to cGMP; and learning or memory. Located in endomembrane system and plasma membrane. Is active in postsynaptic membrane; presynaptic membrane; and serotonergic synapse. Used to study anxiety disorder; depressive disorder; and pulmonary hypertension. Biomarker of Parkinsonism; borna disease; congenital diaphragmatic hernia; and fetal alcohol spectrum disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; anxiety disorder (multiple); depressive disorder (multiple); heart disease (multiple); and substance abuse (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4). [provided by Alliance of Genome Resources, Jul 2025]
synonyms	sodium-dependent serotonin transporter 5HT transporter 5HTT Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) serotonin transporter solute carrier family 6 (neurotransmitter transporter), member 4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 SERT Click to show/hide the synonyms
Properties