Protein Name solute carrier family 6 member 4
Organism Rattus norvegicus
Gene ID 25553
Gene Symbol

Slc6a4

UniProt P31652 (SC6A4_RAT)
Relationships Total Number of functionally related compound(s) : 424
Total Number of Articles : 589
Description

solute carrier family 6 member 4

Gene Summary

Enables several functions, including cocaine binding activity; serotonin:sodium symporter activity; and syntaxin-1 binding activity. Involved in several processes, including cellular response to cGMP; cellular response to retinoic acid; and negative regulation of dopaminergic synaptic transmission. Located in several cellular components, including membrane raft; neuron projection; and synapse. Is active in serotonergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study anxiety disorder; mental depression; and pulmonary hypertension. Biomarker of Parkinsonism and borna disease. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; alexithymia; anxiety disorder (multiple); heart disease (multiple); and mental depression (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • sodium-dependent serotonin transporter
  • 5HT transporter
  • 5HTT
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Properties