Pub. Date : 2015 Nov 24
PMID : 26603472
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The S phase arrest is proposed to stem from a defect in Mec1-mediated degradation of Sml1, a conserved inhibitor of ribonucleotide reductase (RNR), causing a severe depletion in cellular dNTP pools. | Parathion | protein kinase MEC1 | Saccharomyces cerevisiae S288C |
| 2 | Here, the casual link between the S phase arrest, Sml1, and dNTP-levels is examined using a temperature sensitive mec1 mutant. | Parathion | protein kinase MEC1 | Saccharomyces cerevisiae S288C |
| 3 | The dNTP pool in mec1 is reduced by ~17% and GIS2 expression restores it, but only partially, to ~93% of a control. | Parathion | protein kinase MEC1 | Saccharomyces cerevisiae S288C |
| 4 | Furthermore, unexpectedly modest effects of mec1 and GIS2 on dNTP levels suggest that the S phase arrest is unlikely to result from a severe depletion of dNTP pool as assumed, but a heightened sensitivity to small changes in its availability. | Parathion | protein kinase MEC1 | Saccharomyces cerevisiae S288C |