Pub. Date : 2015 Nov
PMID : 26592832
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Western blot analysis was used to detect the protein expression of RECK, matrix metalloproteinase (MMP)-2 and MMP-9 in celecoxib-treated MG-63 cells. | Celecoxib | matrix metallopeptidase 9 | Homo sapiens |
| 2 | Western blot analyses revealed that the expression of MMP-2 and MMP-9 was markedly down-regulated but RECK, an inhibitor of MMPs, was markedly up-regulated in MG-63 cells exposed to 20 microg/ml celecoxib for 24 or 48h. | Celecoxib | matrix metallopeptidase 9 | Homo sapiens |
| 3 | Celecoxib-induced down-regulation of MMP-2 and MMP-9 and up-regulation of RECK may contribute to the apoptosis induction and an alteration in local tumor microenvironment. | Celecoxib | matrix metallopeptidase 9 | Homo sapiens |
| 4 | These findings suggest that celecoxib may exert at least in part of its anticancer effects via up-regulation of RECK to inhibit the expression of MMP-2 and MMP-9. | Celecoxib | matrix metallopeptidase 9 | Homo sapiens |