PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26592832-5 2015 Western blot analysis was used to detect the protein expression of RECK, matrix metalloproteinase (MMP)-2 and MMP-9 in celecoxib-treated MG-63 cells. Celecoxib 119-128 matrix metallopeptidase 9 Homo sapiens 110-115 26592832-10 2015 Western blot analyses revealed that the expression of MMP-2 and MMP-9 was markedly down-regulated but RECK, an inhibitor of MMPs, was markedly up-regulated in MG-63 cells exposed to 20 microg/ml celecoxib for 24 or 48h. Celecoxib 195-204 matrix metallopeptidase 9 Homo sapiens 64-69 26592832-13 2015 Celecoxib-induced down-regulation of MMP-2 and MMP-9 and up-regulation of RECK may contribute to the apoptosis induction and an alteration in local tumor microenvironment. Celecoxib 0-9 matrix metallopeptidase 9 Homo sapiens 47-52 26592832-14 2015 These findings suggest that celecoxib may exert at least in part of its anticancer effects via up-regulation of RECK to inhibit the expression of MMP-2 and MMP-9. Celecoxib 28-37 matrix metallopeptidase 9 Homo sapiens 156-161