Title : Simvastatin Reduces Lipopolysaccharides-Accelerated Cerebral Ischemic Injury via Inhibition of Nuclear Factor-kappa B Activity.

Pub. Date : 2015 Nov

PMID : 26535078






1 Functional Relationships(s)
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1 Treatment of simvastatin reduced the LPS-accelerated infarct size by 73%, and decreased the ischemia/reperfusion-induced expressions of pro-inflammatory mediators such as iNOS, COX-2 and IL-1beta in LPS-injected rat brains. Simvastatin nitric oxide synthase 2 Rattus norvegicus