Pub. Date : 2016
PMID : 26484920
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have shown in this study that chelatable iron accumulates in the aged rat brain along with overexpression of transferrin receptor 1 (TfR1) and ferritin, accompanied by significant alterations in amyloid-beta (Abeta) peptide homeostasis in the aging brain, such as an increased production of the amyloid-beta protein precursor, a decreased level of neprilysin, and increased accumulation of Abeta42. | Iron | transferrin receptor | Rattus norvegicus |
| 2 | We have shown in this study that chelatable iron accumulates in the aged rat brain along with overexpression of transferrin receptor 1 (TfR1) and ferritin, accompanied by significant alterations in amyloid-beta (Abeta) peptide homeostasis in the aging brain, such as an increased production of the amyloid-beta protein precursor, a decreased level of neprilysin, and increased accumulation of Abeta42. | Iron | transferrin receptor | Rattus norvegicus |
| 3 | When aged rats are given daily the iron chelator, deferasirox, over a period of more than 4 months starting from the 18th month, the age-related accumulation of iron and overexpression of TfR1 and ferritin in the brain are significantly prevented. | Iron | transferrin receptor | Rattus norvegicus |
| 4 | The analysis of the results together suggests that iron accumulation and oxidative stress interact at multiple levels that include transcriptional and post-transcriptional mechanisms to bring about changes in the expression levels of TfR1 and ferritin and also alterations in Abeta peptide metabolism in the aging rat brain. | Iron | transferrin receptor | Rattus norvegicus |