Title : Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity.

Pub. Date : 2015 Dec 4

PMID : 26438821






1 Functional Relationships(s)
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1 Given that the metabolic fate of fatty acids in macrophages is not entirely elucidated, we have hypothesized that de novo synthesis of ceramide, through the rate-limiting enzyme serine palmitoyltransferase long chain (Sptlc)-2, is required for saturated fatty acid-driven Nlrp3 inflammasome activation in macrophages. Ceramides serine palmitoyltransferase, long chain base subunit 2 Mus musculus