PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26438821-4 2015 Given that the metabolic fate of fatty acids in macrophages is not entirely elucidated, we have hypothesized that de novo synthesis of ceramide, through the rate-limiting enzyme serine palmitoyltransferase long chain (Sptlc)-2, is required for saturated fatty acid-driven Nlrp3 inflammasome activation in macrophages. Ceramides 135-143 serine palmitoyltransferase, long chain base subunit 2 Mus musculus 178-226