Pub. Date : 2015 Nov 15
PMID : 26400185
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Folic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism. | Folic Acid | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 2 | The aim of the present study was to investigate the effect of folic acid on hepatic AMPK during high-fat diet feeding and the mechanisms involved. | Folic Acid | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 3 | Folic acid supplementation restored AMPK phosphorylation (activation) and reduced blood glucose and hepatic cholesterol levels. | Folic Acid | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 4 | Activation of AMPK by folic acid was mediated through an elevation of its allosteric activator AMP and activation of its upstream kinase, namely, liver kinase B1 (LKB1) in the liver. | Folic Acid | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 5 | Consistent with in vivo findings, 5-methyltetrahydrofolate (bioactive form of folate) restored phosphorylation (activation) of both AMPK and LKB1 in palmitic acid-treated HepG2 cells. | Folic Acid | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 6 | Activation of AMPK by folic acid might be responsible for AMPK-dependent phosphorylation of HMG-CoA reductase, leading to reduced hepatic cholesterol synthesis during high-fat diet feeding. | Folic Acid | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 7 | Activation of AMPK by folic acid might be responsible for AMPK-dependent phosphorylation of HMG-CoA reductase, leading to reduced hepatic cholesterol synthesis during high-fat diet feeding. | Folic Acid | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 8 | These results suggest that folic acid supplementation may improve cholesterol and glucose metabolism by restoration of AMPK activation in the liver. | Folic Acid | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |