Pub. Date : 2015
PMID : 26399925
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ex vivo studies showed that sitagliptin increased the phosphorylated cAMP response element-binding protein (CREB), which can be reversed by H-89 (a PKA inhibitor), not brefeldin A (an Epac inhibitor).Heme oxygenase-1(HO-1) expression was increased by a PKA agonist but not by an Epac agonist.HO-1expression was attenuated in KG-501 (a CREB inhibitor)-treated infarcted rats in the presence of a PKA agonist. | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |
| 2 | Ex vivo studies showed that sitagliptin increased the phosphorylated cAMP response element-binding protein (CREB), which can be reversed by H-89 (a PKA inhibitor), not brefeldin A (an Epac inhibitor).Heme oxygenase-1(HO-1) expression was increased by a PKA agonist but not by an Epac agonist.HO-1expression was attenuated in KG-501 (a CREB inhibitor)-treated infarcted rats in the presence of a PKA agonist. | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |
| 3 | Ex vivo studies showed that sitagliptin increased the phosphorylated cAMP response element-binding protein (CREB), which can be reversed by H-89 (a PKA inhibitor), not brefeldin A (an Epac inhibitor).Heme oxygenase-1(HO-1) expression was increased by a PKA agonist but not by an Epac agonist.HO-1expression was attenuated in KG-501 (a CREB inhibitor)-treated infarcted rats in the presence of a PKA agonist. | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |