CPRiL

Prkaca

protein kinase cAMP-activated catalytic subunit alpha

Enables cAMP-dependent protein kinase activity; protein kinase binding activity; and small GTPase binding activity. Involved in several processes, including peptidyl-serine phosphorylation; regulation of glutamatergic synaptic transmission; and spontaneous exocytosis of neurotransmitter. Located in perinuclear region of cytoplasm. Part of cAMP-dependent protein kinase complex. Is active in neuromuscular junction; postsynapse; and presynapse. Biomarker of amphetamine abuse and brain ischemia. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; fibrolamellar carcinoma; and primary pigmented nodular adrenocortical disease 4. Orthologous to human PRKACA (protein kinase cAMP-activated catalytic subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]

• cAMP-dependent protein kinase catalytic subunit alpha
• PKA C-alpha
• cAMP-dependent protein kinase catalytic subunit C alpha
protein kinase A
protein kinase, cAMP-dependent, alpha catalytic subunit
protein kinase, cAMP-dependent, catalytic, alpha
Cs-PKA
PKCA1