Pub. Date : 2015 Dec
PMID : 26374173
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Montelukast has been recommended as a selective in vitro and in vivo probe of cytochrome P450 (P450) CYP2C8 activity, but its selectivity toward this enzyme remains unclear. | montelukast | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
2 | Kinetic and inhibition experiments performed at therapeutically relevant concentrations reveal that CYP2C8 and CYP2C9 are the principal enzymes responsible for montelukast 36-hydroxylation to 1,2-diol. | montelukast | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
3 | The utility of montelukast as a probe of CYP2C8 activity may be compromised owing to involvement of multiple P450s and UGT1A3 in its metabolism. | montelukast | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |