Pub. Date : 2015
PMID : 26261550
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | HMGB1 is activated in type 2 diabetes mellitus patients and in mesangial cells in response to high glucose. | Glucose | high mobility group box 1 | Homo sapiens |
| 2 | In the present study, we examined the promotion by high glucose to High-mobility group box-1 (HMGB1) in patients with type 2 diabetes mellitus or in renal mesangial SV40 MES 13 cells. | Glucose | high mobility group box 1 | Homo sapiens |
| 3 | In the present study, we examined the promotion by high glucose to High-mobility group box-1 (HMGB1) in patients with type 2 diabetes mellitus or in renal mesangial SV40 MES 13 cells. | Glucose | high mobility group box 1 | Homo sapiens |
| 4 | The in vitro results indicated that HMGB1 mediated the D-glucose-induced pro-inflammatory cytokines in mesangial cells. | Glucose | high mobility group box 1 | Homo sapiens |
| 5 | In summary, the present study indicated that HMGB1 was significantly promoted by the glucose in vivo or in vitro, in an association with an upregulation of pro-inflammatory cytokines, via activating NF-kappaB signaling pathway. | Glucose | high mobility group box 1 | Homo sapiens |
| 6 | And the strategy of HMGB1 inhibition reduced the upregulation of pro-inflammatory cytokines in response to high glucose, via inhibiting the NF-kappaB signaling pathway. | Glucose | high mobility group box 1 | Homo sapiens |