PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26261550-0	2015	HMGB1 is activated in type 2 diabetes mellitus patients and in mesangial cells in response to high glucose.	Glucose	99-106	high mobility group box 1	Homo sapiens	0-5	
26261550-4	2015	In the present study, we examined the promotion by high glucose to High-mobility group box-1 (HMGB1) in patients with type 2 diabetes mellitus or in renal mesangial SV40 MES 13 cells.	Glucose	56-63	high mobility group box 1	Homo sapiens	67-92	
26261550-4	2015	In the present study, we examined the promotion by high glucose to High-mobility group box-1 (HMGB1) in patients with type 2 diabetes mellitus or in renal mesangial SV40 MES 13 cells.	Glucose	56-63	high mobility group box 1	Homo sapiens	94-99	
26261550-7	2015	The in vitro results indicated that HMGB1 mediated the D-glucose-induced pro-inflammatory cytokines in mesangial cells.	Glucose	55-64	high mobility group box 1	Homo sapiens	36-41	
26261550-9	2015	In summary, the present study indicated that HMGB1 was significantly promoted by the glucose in vivo or in vitro, in an association with an upregulation of pro-inflammatory cytokines, via activating NF-kappaB signaling pathway.	Glucose	85-92	high mobility group box 1	Homo sapiens	45-50	
26261550-10	2015	And the strategy of HMGB1 inhibition reduced the upregulation of pro-inflammatory cytokines in response to high glucose, via inhibiting the NF-kappaB signaling pathway.	Glucose	112-119	high mobility group box 1	Homo sapiens	20-25