Pub. Date : 2015 Oct 1
PMID : 26225832
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures. | Acetaminophen | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 2 | Herein, we demonstrated that in vitro CYP2E1 metabolic activation of acetaminophen and styrene mixtures could not be explained through the Michaelis-Menten mechanism or any models relying on that premise. | Acetaminophen | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 3 | In this case, acetaminophen competed with styrene for CYP2E1 (Ki=830muM and Ksi=180muM for catalytic and effector sites, respectively) and resulted in cooperative impacts on binding and catalysis. | Acetaminophen | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |