Title : Hexachlorobenzene induces cell proliferation, and aryl hydrocarbon receptor expression (AhR) in rat liver preneoplastic foci, and in the human hepatoma cell line HepG2. AhR is a mediator of ERK1/2 signaling, and cell cycle regulation in HCB-treated HepG2 cells.

Pub. Date : 2015 Oct 2

PMID : 26219504






4 Functional Relationships(s)
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1 AhR is a mediator of ERK1/2 signaling, and cell cycle regulation in HCB-treated HepG2 cells. Hexachlorobenzene aryl hydrocarbon receptor Homo sapiens
2 In a similar manner, Western blot analysis demonstrated that HCB induced PCNA and AhR protein expression in HepG2 cells. Hexachlorobenzene aryl hydrocarbon receptor Homo sapiens
3 Pretreatment with an AhR antagonist, prevented HCB-induced PCNA protein levels, ERK1/2 phosphorylation and alterations in cell cycle distribution. Hexachlorobenzene aryl hydrocarbon receptor Homo sapiens
4 These results demonstrate that HCB-induced HepG2 proliferation and cell cycle progression depend on ERK1/2 phosphorylation which is mediated by the AhR. Hexachlorobenzene aryl hydrocarbon receptor Homo sapiens