Pub. Date : 2016 Jan
PMID : 26089182
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The anxiolytic drug buspirone has been proposed as a potential strategy as findings suggest that this drug has high in vitro affinity for DRD3, binds to DRD3 in brain of living non-human primate, and also disrupts psychostimulant self-administration in preclinical models. | Buspirone | dopamine receptor D3 | Homo sapiens |
| 2 | The anxiolytic drug buspirone has been proposed as a potential strategy as findings suggest that this drug has high in vitro affinity for DRD3, binds to DRD3 in brain of living non-human primate, and also disrupts psychostimulant self-administration in preclinical models. | Buspirone | dopamine receptor D3 | Homo sapiens |
| 3 | No study has explored the occupancy of DRD3 by buspirone in humans. | Buspirone | dopamine receptor D3 | Homo sapiens |
| 4 | Here, we used positron emission tomography (PET) and the D3-preferring probe, [(11)C]-(+)-PHNO, to test the hypothesis that buspirone will occupy (decreases [(11)C]-(+)-PHNO binding) the DRD3 more readily than the DRD2. | Buspirone | dopamine receptor D3 | Homo sapiens |
| 5 | [(11)C]-(+)-PHNO binding in DRD2- and DRD3-rich areas was decreased by the highest (60-120 mg), but not the lowest (30 mg), doses of buspirone. | Buspirone | dopamine receptor D3 | Homo sapiens |