Protein Name dopamine receptor D3
Organism Homo sapiens
Gene ID 1814
Gene Symbol


UniProt P35462 (DRD3_HUMAN), X5D2G4 (X5D2G4_HUMAN), E9PCM4 (E9PCM4_HUMAN), A8K8E4 (A8K8E4_HUMAN), A1A4V4 (A1A4V4_HUMAN)
Relationships Total Number of functionally related compound(s) : 92
Total Number of Articles : 211

dopamine receptor D3

Gene Summary

This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

  • D(3) dopamine receptor
  • essential tremor 1
  • D3DR
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