Title : The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.

Pub. Date : 2015 May 19

PMID : 25990959






3 Functional Relationships(s)
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1 The data indicated that the kinase activity of ZAP-70 stimulates negative feedback pathways that target Lck and thereby modulate the phosphorylation patterns of the immunoreceptor tyrosine-based activation motifs (ITAMs) of the CD3 and zeta chain components of the TCR and of signaling molecules downstream of Lck, including ZAP-70. Tyrosine LCK proto-oncogene, Src family tyrosine kinase Homo sapiens
2 The data indicated that the kinase activity of ZAP-70 stimulates negative feedback pathways that target Lck and thereby modulate the phosphorylation patterns of the immunoreceptor tyrosine-based activation motifs (ITAMs) of the CD3 and zeta chain components of the TCR and of signaling molecules downstream of Lck, including ZAP-70. Tyrosine LCK proto-oncogene, Src family tyrosine kinase Homo sapiens
3 This model incorporated negative feedback regulation of Lck activity by the kinase activity of ZAP-70 and predicted the order in which tyrosines in the ITAMs of TCR zeta chains must be phosphorylated to be consistent with the experimental data. Tyrosine LCK proto-oncogene, Src family tyrosine kinase Homo sapiens