PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25990959-4	2015	The data indicated that the kinase activity of ZAP-70 stimulates negative feedback pathways that target Lck and thereby modulate the phosphorylation patterns of the immunoreceptor tyrosine-based activation motifs (ITAMs) of the CD3 and zeta chain components of the TCR and of signaling molecules downstream of Lck, including ZAP-70.	Tyrosine	180-188	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	104-107	
25990959-4	2015	The data indicated that the kinase activity of ZAP-70 stimulates negative feedback pathways that target Lck and thereby modulate the phosphorylation patterns of the immunoreceptor tyrosine-based activation motifs (ITAMs) of the CD3 and zeta chain components of the TCR and of signaling molecules downstream of Lck, including ZAP-70.	Tyrosine	180-188	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	310-313	
25990959-6	2015	This model incorporated negative feedback regulation of Lck activity by the kinase activity of ZAP-70 and predicted the order in which tyrosines in the ITAMs of TCR zeta chains must be phosphorylated to be consistent with the experimental data.	Tyrosine	135-144	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	56-59