CPRiL

LCK

LCK proto-oncogene, Src family tyrosine kinase

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016]

• tyrosine-protein kinase Lck
• T-lymphocyte specific protein tyrosine kinase p56lck
• leukocyte C-terminal Src kinase
lymphocyte cell-specific protein-tyrosine kinase
p56(LSTRA) protein-tyrosine kinase
proto-oncogene tyrosine-protein kinase LCK
t cell-specific protein-tyrosine kinase
IMD22
LSK
YT16
p56lck
pp58lck