Protein Name LCK proto-oncogene, Src family tyrosine kinase
Organism Homo sapiens
Gene ID 3932
Gene Symbol


UniProt P06239 (LCK_HUMAN), Q573B4 (Q573B4_HUMAN), A0A0S2Z3Y8 (A0A0S2Z3Y8_HUMAN), A0A0S2Z3Y4 (A0A0S2Z3Y4_HUMAN)
Relationships Total Number of functionally related compound(s) : 378
Total Number of Articles : 762

LCK proto-oncogene, Src family tyrosine kinase

Gene Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016]

  • tyrosine-protein kinase Lck
  • T-lymphocyte specific protein tyrosine kinase p56lck
  • leukocyte C-terminal Src kinase
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