Pub. Date : 2015 Aug
PMID : 25986850
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ginsenosides Regulate PXR/NF-kappaB Signaling and Attenuate Dextran Sulfate Sodium-Induced Colitis. | Ginsenosides | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Here we found that ginsenosides restore PXR/NF-kappaB signaling in inflamed conditions without disrupting PXR function in normal conditions. | Ginsenosides | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | The effects and mechanisms of ginsenosides in regulating PXR/NF-kappaB signals were determined both in vitro and in vivo. | Ginsenosides | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Ginsenosides significantly inhibited NF-kappaB activation and restored the expression of PXR target genes in tumor necrosis factor-alpha-stimulated LS174T cells. | Ginsenosides | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | Despite not being PXR agonists, ginsenosides repressed NF-kappaB activation in a PXR-dependent manner. | Ginsenosides | nuclear factor kappa B subunit 1 | Homo sapiens |
| 6 | Ginsenosides significantly increased the physical association between PXR and the NF-kappaB p65 subunit and thereby decreased the nuclear translocation of p65. | Ginsenosides | nuclear factor kappa B subunit 1 | Homo sapiens |
| 7 | Consistently, ginsenosides significantly attenuated dextran sulfate sodium-induced experimental colitis, which was associated with restored PXR/NF-kappaB signaling. | Ginsenosides | nuclear factor kappa B subunit 1 | Homo sapiens |
| 8 | This study indicates that ginsenosides may elicit anti-inflammatory effects via targeting PXR/NF-kappaB interaction without disrupting PXR function in healthy conditions. | Ginsenosides | nuclear factor kappa B subunit 1 | Homo sapiens |