Title : Antiproliferative Activity of Hinokitiol, a Tropolone Derivative, Is Mediated via the Inductions of p-JNK and p-PLCĪ³1 Signaling in PDGF-BB-Stimulated Vascular Smooth Muscle Cells.

Pub. Date : 2015 May 7

PMID : 25961161






2 Functional Relationships(s)
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1 Antiproliferative Activity of Hinokitiol, a Tropolone Derivative, Is Mediated via the Inductions of p-JNK and p-PLCgamma1 Signaling in PDGF-BB-Stimulated Vascular Smooth Muscle Cells. beta-thujaplicin phospholipase C gamma 1 Homo sapiens
2 Taken together, our results suggest that hinokitiol inhibits PDGF-BB-induced proliferation of VSMCs by inducing cell cycle arrest, suppressing JNK1/2 phosphorylation and PLC-gamma1, and stimulating p27kip1 expression. beta-thujaplicin phospholipase C gamma 1 Homo sapiens