Protein Name phospholipase C gamma 1
Organism Homo sapiens
Gene ID 5335
Gene Symbol


UniProt P19174 (PLCG1_HUMAN), Q4LE43 (Q4LE43_HUMAN), Q9UFY1 (Q9UFY1_HUMAN)
Relationships Total Number of functionally related compound(s) : 278
Total Number of Articles : 485

phospholipase C gamma 1

Gene Summary

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

  • 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
  • 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
  • PLC-148
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