Title : FOLFOX4 plus cetuximab treatment and RAS mutations in colorectal cancer.

Pub. Date : 2015 Jul

PMID : 25937522






1 Functional Relationships(s)
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1 BACKGROUND: The OPUS study demonstrated that addition of cetuximab to 5-fluorouracil, folinic acid and oxaliplatin (FOLFOX4) significantly improved objective response and progression-free survival (PFS) in the first-line treatment of patients with KRAS exon 2 wild-type metastatic colorectal cancer (mCRC). Leucovorin KRAS proto-oncogene, GTPase Homo sapiens