PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25937522-1 2015 BACKGROUND: The OPUS study demonstrated that addition of cetuximab to 5-fluorouracil, folinic acid and oxaliplatin (FOLFOX4) significantly improved objective response and progression-free survival (PFS) in the first-line treatment of patients with KRAS exon 2 wild-type metastatic colorectal cancer (mCRC). Leucovorin 86-98 KRAS proto-oncogene, GTPase Homo sapiens 248-252