Title : Targeting the EWS-FLI1 transcription factor in Ewing sarcoma.

Pub. Date : 2015 Jun

PMID : 25809543






1 Functional Relationships(s)
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1 PURPOSE: Preclinical data indicate there is strong synergism of action against Ewing sarcoma in sequential treatment with trabectedin followed by irinotecan and it appears to be related to a selective blockade of the transcription factor EWS-FLI1. Trabectedin Fli-1 proto-oncogene, ETS transcription factor Homo sapiens