PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25809543-1 2015 PURPOSE: Preclinical data indicate there is strong synergism of action against Ewing sarcoma in sequential treatment with trabectedin followed by irinotecan and it appears to be related to a selective blockade of the transcription factor EWS-FLI1. Trabectedin 122-133 Fli-1 proto-oncogene, ETS transcription factor Homo sapiens 242-246