Title : Overexpression of survivin via activation of ERK1/2, Akt, and NF-κB plays a central role in vincristine resistance in multiple myeloma cells.

Pub. Date : 2015 Apr

PMID : 25726084






2 Functional Relationships(s)
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1 In this study, we investigated the mechanism of MDR in RPMI8226/VCR cells, and found that RPMI8226/VCR cells exhibit increased levels of activated ERK1/2, Akt, and NF-kappaB, while the levels of activated mTOR, p38MAPK, and JNK do not differ between RPMI8226/VCR cells and their vincristine-susceptible counterparts. rpmi8226 nuclear factor kappa B subunit 1 Homo sapiens
2 In addition, the inhibition of ERK1/2, Akt, or NF-kappaB by inhibitors reversed the drug-resistance of RPMI8226/VCR cells via the suppression of survivin expression, but did not affect MDR1 expression; RNA silencing of survivin expression completely reversed vincristine resistance, while MDR1 silencing only weakly suppressed vincristine resistance in RPMI8226/VCR cells. rpmi8226 nuclear factor kappa B subunit 1 Homo sapiens