PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25726084-4	2015	In this study, we investigated the mechanism of MDR in RPMI8226/VCR cells, and found that RPMI8226/VCR cells exhibit increased levels of activated ERK1/2, Akt, and NF-kappaB, while the levels of activated mTOR, p38MAPK, and JNK do not differ between RPMI8226/VCR cells and their vincristine-susceptible counterparts.	rpmi8226	90-98	nuclear factor kappa B subunit 1	Homo sapiens	164-173	
25726084-5	2015	In addition, the inhibition of ERK1/2, Akt, or NF-kappaB by inhibitors reversed the drug-resistance of RPMI8226/VCR cells via the suppression of survivin expression, but did not affect MDR1 expression; RNA silencing of survivin expression completely reversed vincristine resistance, while MDR1 silencing only weakly suppressed vincristine resistance in RPMI8226/VCR cells.	rpmi8226	103-111	nuclear factor kappa B subunit 1	Homo sapiens	47-56